Philippe Senderos was a free agent when he signed for London team Fulham. The Swiss international signed for the Craven Cottage outfit on June 8, 2010. Philippe Senderos put pen to paper on a three-year deal to become a Fulham player.

Senderos was unlucky at the start of his career at Fulham after he sustained a serious injury. He tore his Achilles tendon in training some weeks after signing for the club. The serious injury happened in training on August 9, 2020. Afterwards, Senderos was ruled out for six months meaning that he had to wait to play his first game for the Cottagers competitively.

Senderos underwent surgery on the damaged Achilles and he had to wait till the end of his debut season to play his first game for Fulham. His debut was on April 30, 2011. Philippe Senderos played for the West London club for the first time against Sunderland. Around a year later, the retired Swiss national team player found the back of the net in Fulhamcolours for the first time.

Philippe Senderos scored one of the goals as Fulham beat Wigan Athletic 2-1 at home in what was a Premier League encounter. The goal against the Laticsas scored by Senderos was on April 21, 2021.

Swiss international Senderos was a regular in the Fulham team on the back of the Achilles injury that made him the start of his career at Fulham. Senderos made up for lost time while he was on the sidelines with his performances and it was not surprising that he was offered a new deal until 2014.Fulham gave the ex-Arsenal centre back a one-year extension on March 1, 2013. The new deal took him to the summer of 2014.

Senderos left Fulham for Valencia in January 2014 when he had six months left on his contract at the Craven Cottage.